Over the years I’ve tried to fix my leaky gut, dislodge pathogens, improve digestion, correct methylation and balance neurotransmitters for better sleep. In the process, I had to experiment with a ton of supplements and most of the time had negative reactions. This is a list of the particularly bad boys that caused wacky, mysterious, paradoxical reactions.
Interestingly, every single one of these are reported to help sleep in one way or another but not for me. I’ll update this list as I go along on my quest to recovery. If you see a link then I’ve either written about it or created a video.
Glycine – initial experience was good: felt rather relaxed, a bit tired (not fatigued) but eventually worsened my insomnia. I learned later that glycine can actually make things much worse. Being attractive as a GABA precursor it can rapidly turn nasty in ceratin people and convert to Glutamate – a neuroexcitatory neurotransmitter.
L-Glutamine – this one a real devil. First, I felt very relaxed from it but then a day later very alert at night, slight buzzing sound in my head. Insomnia was much worse and lasted quite a few nights. Will never touch it again. My guess is this was due to GABA/Glutamine imbalance and my body being sympathetic dominant.
NAC – buzzy feeling, alert, makes insomnia worse. Had high hopes for it because many people report improved methylation and liver detox function, however it didn’t work out for me.
Molybdenum – is somewhat helpful in digestion process by supporting the liver detox but recommended doses cause fatigue. Even half a dose every other day causes unpleasant levels of fatigue. Yet another supplement that helps the liver but creates another imbalance.
Vitamin B12 (methylcobalamin) – gives me more energy but again makes me more alert and sleepless at night.
Biotine – holy cow, what madness is this? I took a regular dose and had massive alertness from it that lasted several days. Even a tiny dose will make me feel ampped up day and night. Can not take as it makes me very alert at night.
Inositol – suppose to be calming and help liver detox but made insomnia worse by increasing body heat.
Milk Thistle – very promising at first as I felt less heat at night and more energy during the day. This is due to improved liver detox. Three days later it causes massive fatigue and I can hardly drag my feet. What’s up with this?
Licorice – supposedly helps with adrenal fatigue but actually caused massive fatigue as soon as I take it. Tried it a few times and had same reaction.
Pantothenic Acid – touted as the No. 1 supplement to prop up the adrenals. The first day I took it I had a great night’s sleep and thought I had found my cure. Second night was about the same but things came back to “normal” the third night. Never worked afterwards.
Maca root – another popular adaptogen for adrenal fatigue that backfired. Initially, I felt more energetic and really thought I had found my perfect herb. I had increased stamina and mood for a total of….. two days. Then I crashed. Had I known Maca is actually a “Peruvian ginseng” I would have stayed away from it. With advanced stages of adrenal fatigue any heating stimulants like ginseng are a total ‘no no’.
I know, for a fact, all these reaction are pointing into some underlying health issues that have to do with toxicity, methylation issues and mineral imbalance. Problem is only a very experienced physician would be able to tell what all these reactions are indicative of.
If you’ve had your share of bad experiences with supplements I’d love to hear about them, especially the worst types!